MIPI: Mantle Cell Lymphoma International Prognostic Index

Background

The clinical course of mantle cell lymphoma (MCL) is highly variable. Lower age, better performance status, lower serum lactate-dehydrogenase (LDH) activity, and lower white blood cell (WBC) count at first diagnosis have been shown to be associated with longer progression-free and overall survival in patients with MCL suitable for moderately intensive chemotherapy. Furthermore, the tumour cell proliferation rate Ki-67 index has been identified as strong prognostic marker additional to clinical patient characteristics.

The Mantle Cell Lymphoma International Prognostic Index (MIPI, Hoster et al., Blood 2008) assigns MCL patients to three prognostic groups according to the diagnostic values of the clinical variables age, ECOG performance status, serum LDH activity, and WBC count. When the Ki-67 index evaluated on diagnostic tumour tissue is available, the more refined combined MIPI (MIPI-c, Hoster et al., JCO 2016) can be assessed that classifies MCL patients into four prognostic groups dependent on MIPI group and Ki-67 index. For the assessment of the Ki-67 index, guidelines published by the European MCL Pathology Panel are available (Klapper et al., Journal of Hematopathology, 2009).

Calculator

Please choose whether MIPI or MIPI-c should be calculated. Then enter diagnostic values of age in years, ECOG performance status, LDH, and WBC count in G/L. For LDH the upper limit of normal (ULN) is also required using the same unit. MIPI assigns a patient to the low, intermediate, or high risk group. For the evaluation of MIPI-c, please additionally enter the Ki-67 index in % assessed on diagnostic tumour tissue. According to MIPI-c a patient is assigned to the low, low-intermediate, high-intermediate, or high risk group.

The values of ECOG performance status (Oken at al. 1982) are defined as follows.

0Fully active, able to carry on all pre-disease performance without restriction
1Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g., light house work, office work
2Ambulatory and capable of all selfcare but unable to carry out any work activities. Up and about more than 50% of waking hours
3Capable of only limited selfcare, confined to bed or chair more than 50% of waking hours
4Completely disabled. Cannot carry on any selfcare. Totally confined to bed or chair

By using this calculator you accept that the European MCL Network does not assume any liability.

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(c) 2016 European MCL Network